Products - 3D Bioreactor
A Novel 3D Perfusion Bioreactor From 3D Biotek!
Product Info |
Detailed Part List - Standard, Budget 1 and Budget 2 Packages |
Published Poster |
User Manual |
CAD model of chamber/scaffolds assembly
Numerous studies have proven that cells grow better under dynamic culture condition,
simply because both nutrition supply and metabolic waste removal are better under
dynamic culture conditions. Additionally, in some instances, the shear force produced
by the flowing medium can act as a mechanical stimuli signal that will further promote
stem cell differentiation toward certain cell lineage, such as osteoblast. Combined
with our proven 3D InsertTM scaffold technology, we are very pleased to announce
that we have launched a novel 3D Perfusion Bioreactor.
3D Perfusion Bioreactor
The bioreactor consists of multiple independent, autoclavable polycarbonate chambers
(4 chambers as shown in the picture). The chambers are interchangeable and are specially
designed to take the advantage of 3D InsertTM scaffolds with various sizes ranging
from 96-well to 6-well. Cell culture medias are perfused through the open porous
structure of scaffolds using a pulsatile pump. The entire unit is autoclavable (except
pump, of course) and can be used as a single-use bioreactor system.
3D InsertTM Technology
Porous polymer scaffolds were engineered using 3D Biotek’s Proprietary Precision
Microfabrication Technology. These scaffolds are available in both biodegradable
(polycaprolactone, PCL) (Figure A). and non-biodegradable (polystyrene, PS) polymers.
Struts of each layer of the scaffolds are oriented 90° relative to the struts
of the layer immediately below (Figures B-C, scanning electron micrographs). Not
only that 3D InsertTM will provide a 3D cell culture environment, but
also will provide a significantly greater total cell growth
area than that of a traditional 2D tissue culture well.
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